NIH Molecular Libraries Probe Production Centers Network (MLPCN)

Probe Reports

Patrick Faloon, Warren S. Weiner, Daljit S. Matharu, Benjamin Neuenswander, Patrick Porubsky, Willmen Youngsaye, Melissa Bennion, Wai-Leung Ng, Amanda Hurley, Carrie M. Mosher, Stephen Johnston, Sivaraman Dandapani, Frank J. Schoenen, Jeffrey Aubé, Benito Munoz, Michelle Palmer, Bonnie L. Bassler, and Stuart L. Schreiber. “Discovery of ML 370, an inhibitor of Vibrio cholerae Quorum Sensing Acting via the LuxO response regulator.” 2013 Apr 12 [updated 2014 Jan 13]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK189926/ PMID: 24624467

Frank J. Schoenen, Warren S. Weiner, Pierre Baillargeon, Christopher L. Brown, Peter Chase, Jill Ferguson, Virneliz Fernandez-Vega, Partha Ghosh, Peter Hodder, Jeffrey P. Krise, Daljit S. Matharu, Benjamin Neuenswander, Patrick Porubsky, Steven Rogers, Tina Skinner-Adams, Melinda Sosa, Timothy Spicer, Joyce To, Nichole A. Tower, Katharine R. Trenholme, Jenna Wang, David Whipple, Jeffrey Aubé, Hugh Rosen, E. Lucile White, John P. Dalton, and Donald L. Gardiner. “Inhibitors of the Plasmodium falciparum M18 Aspartyl Aminopeptidase.” 2013 Apr 15. [updated 2013 Nov 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK179825/ PMID  24479194

Beiyan Zou, Daniel P. Flaherty, Denise S. Simpson, Brooks E. Maki, Melissa R. Miller, Jie Shi, Meng Wu, Owen B. McManus,, Jeffrey Aubé, and Min Li. “ML365: Development of Bis-Amides as Selective Inhibitors of the KCNK3/TASK1 Two Pore Potassium Channel.” 2013 Apr 15 [updated 2013 Nov 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK179826/ PMID 24479195

Donghoon Chung, Chad E. Schroeder, Julie Sotsky, Tuanli Yao, Sudeshna Roy, Robert A. Smith, Nichole A. Tower, James W. Noah, Sara McKellip, Melinda Sosa, Lynn Rasmussen, E. Lucile White, Jeffrey Aubé, and Jennifer E. Golden. “ML336: Development of Quinazolinone-Based Inhibitors Against Venezuelan Equine Encephalitis Virus (VEEV).” 2012 Dec 17 [updated 2013 Nov 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK179829/ PMID  24479198

Noah, J. W.; Ananthan, S.; Evans, C. W.; Nebane, N. M.; Rasmussen, L.; Sosa, M.; Tower, N. A.; White, E. L.; Seed, P.; Goller, C.; Arshad, M.; Datta, A.; Neuenswander, B.; Porubsky, P.; Maki, B. E.; Liu, C.; Rogers, S. A.; Schoenen, F.; Aubé, J. "N-(pyridin-4-yl)benzo[d]thiazole-6-carboxamide inhibits E. coli UT189 bacterial capsule biogenesis." 2012 Dec 17 [updated 2013 Apr 5]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK148500/ PMID: 23833802.

Faloon, P. W.; Bennion, M.; Weiner, W. S.; Smith, R. A.; Wurst, J.; Weiwer, M.; Hartland, C.; Mosher, C. M.; Johnston, S.; Porubsky, P.; Neuenswander, B.; Dandapani, S.; Munoz, B.; Schoenen, F. J.; Metkar, S.; Haq, R.; Fisher, D. E.; Aubé, J.; Palmer, M; Schreiber, S. L. "A Small Molecule Inhibitor of the MITF Molecular Pathway." 2012 Dec 13 [updated 2013 Apr 5]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK154496/ PMID: 24027801.

Miller, M. R.; Zou, B.; Shi, J.; Flaherty, D. P.; Simpson, D. S.; Yao, T.; Maki, B. E.; Day, V. W.; Douglas, J. T.; Wu, M.; McManus, O. B.; Golden, J. E.; Aubé, J.; Li, M. "Development of a Selective Chemical Inhibitor for the Two-Pore Potassium Channel, KCNK9." 2012 Apr 16 [updated 2013 Feb 28]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133427/ PMID: 23658958.

Noah, J. W.; Ananthan, S.; Evans, C. W.; Nebane, N. M.; Rasmussen, L.; Sosa, M.; Tower, N. A.; White, E. L.; Seed, P.; Goller, C.; Datta, A.; Neuenswander, B.; Porubsky, P.; Maki, B. E.; Rogers, S. A.; Schoenen, F.; Aubé, J. "3-(2,6-difluorobenzamido)-5-(4-ethoxyphenyl) thiophene-2-carboxylic acid inhibits E.coli UT189 bacterial capsule biogenesis." 2012 Apr 16 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143534/ PMID: 23762949.

Coombs, T. C.; Tanega, C.; Shen, M.; Neuenswander, B.; Porubsky, P.; Wang, J. L.; Misteli, T.; Auld, D. S.; Schoenen, F.; Thomas, C. J.; Aubé, J." Identification of selective inhibitors of cdc2-like kinases 1 and 4 (Clk1, Clk4)." 2012 Apr 16 [updated 2013 May 8]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From: http://www.ncbi.nlm.nih.gov/books/NBK153503/ PMID: 23926621.

Flaherty, D. P.; Golden, J. E.; Liu, C.; Hedrick, M.; Gosalia, P.; Li, Y.; Milewski, M.; Sugarman, E.; Suyama, E.; Nguyen, K.; Vasile, S.; Salaniwal, S.; Stonich, D.; Su, Y.; Mangravita-Novo, A.; Vicchiarelli, M.; Smith, L. H.; Diwan, J.; Chung, T. D. Y.; Pinkerton, A. B.; Aubé, J.; Miller, J. R.; Garshott, D. M.; Callaghan, M. U.; Fribley, A. M.; Kaufman, R. J." Selective small molecule activator of the apoptotic arm of the UPR." 2012 Apr 01 [updated 2013 Feb 28]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133431/ PMID: 23658962.

Rogers, S.; Patnaik, S.; Schoenen, F.; Zheng, W.; Choi, J.; Motabar, O.; Southall, N.; Westbroek, W.; Goldin, E.; Sidransky, E.; Leister, W.; Marugan, J. J.; Aubé, J. "Discovery, SAR, and Biological Evaluation of Non-inhibitory Chaperones of Glucocerebrosidase." 2012 Mar 27 [updated 2013 Mar 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143537/ PMID: 23762943.

Hong, L.; Simons, P.; Waller, A.; Strouse, J.; Surviladze, Z.; Ursu, O.; Bologa, C.; Gouveia, K.; Agola, J. O.; BasuRay, S.; Wandinger-Ness, A.; Sklar, L.; Simpson, D. S.; Schroeder, C. E.; Golden, J. E.; Aubé, J. "A small molecule pan-inhibitor of Ras-superfamily GTPases with high efficacy towards Rab7." 2011 Dec 16 [updated 2013 Mar 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143553/ PMID: 23762935.

Li, K.; Frankowski, K. J.; Hanson, A. M.; Ndjomou, J.; Shanahan, M. A.; Mukherjee, S.; Kolli, R.; Shadrick, W. R.; Sweeney, N. L.; Belon, C. A.; Neuenswander, B.; Ferguson, J.; Aubé, J.; Schoenen, F. J.; Blagg, B. S. J.; Frick, D. N. "Hepatitis C Virus NS3 Helicase Inhibitor Discovery." 2011 Dec 16 [updated 2013 Mar 14]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143540/ PMID: 23762946.

Noah, J. W.; Severson, W. E.; Chung, D. H.; Moore, B.; Jia, F.; Xu, X.; Maddox, C.; Rasmussen, L.; Sosa, M. I.; Tower, N. A.; Ananthan, S.; Evans, C. W.; White, E. L.; Jonsson, C.; Matharu, D. S.; Flaherty, D. P.; Simpson, D. S.; Golden, J. E.; Aubé, J. "Identification of a Series of Quinazolinediones as Potent, Selective, Post-Entry Inhibitors of Human Respiratory Syncytial Virus (hRSV) via a Cell-Based High Throughput Screen and Chemical Optimization." 2011 Dec 16 [updated 2013 Feb 28]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133445/ PMID: 23658939.

Frankowski, K.; Patnaik, S.; Schoenen, F.; Huang, S.; Norton, J.; Wang, C.; Titus, S.; Ferrer, M.; Zheng, W.; Southall, N.; Day, V. W.; Aubé, J.; Marugan, J. J. "Discovery and Development of Small Molecules That Reduce PNC Prevalence." 2011 Nov 15 [updated 2013 Jul 24]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143533/ PMID: 23762948.

Chen, J.; Young, S. M.; Allen, C.; Waller, A.; Ursu, O.; Strouse, J. J.; Yao, T.; Golden, J. E.; Peterson, B. R.; Foutz, T. D.; Chavez, S. E.; Perez, D.; Evangelisti, A. M.; Garcia, M. J.; Bologa, C. G.; Carter, M. B.; Salas, V. M.; Oprea, T. I.; Edwards, B. S.; Panchaud, N.; De Virgilio, C.; Seeber, A.; Loewith, R.; Manzanilla, E.; Werner-Washburne, M.; Aubé, J.; Sklar, L. A. "Profiling a Selective Probe for RTG Branch of Yeast TORC1 Signaling Pathway." 2011 Apr 15 [updated 2013 Feb 25]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133439/ PMID: 23658946.

Noah, J. W.; Severson, W.; Chung, D. H.; Moore, B.; Jia, F.; Xu, X.; Maddox, C.; Rasmussen, L.; Sosa, M. I.; Tower, N. A.; Ananthan, S.; White, E. L.; Jonsson, C.; Matharu, D. S.; Golden, J. E.; Prisinzano, T. E.; Aubé, J. "A Cell Based HTS Approach for the Discovery of New Inhibitors of RSV." 2011 Apr 15 [updated 2013 Feb 28]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133442/ PMID: 23658949.

White, E. L.; Maddox, C.; Nebane, N. M.; Tower, N. A.; McKellip, S.; Manuvakhova, A.; Reddy, L.; Sosa, M.; Rasmussen, L.; Whig, K.; Ananthan, S.; Lun, S.; Bishai, W.; Weiner, W. S.; Schoenen, F.; Dutta, A.; Aubé, J. "Discovery and Development of Highly Potent Inhibitors of Mycobacterium tuberculosis Growth In Vitro.2011 Apr 15 [updated 2013 Mar 7]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK143189/ PMID: 23762923.

Chou, T. F.; Li, K.; Nordin, B. E.; Porubsky, P.; Frankowski, K.; Patricelli, M. P.; Aubé, J.; Schoenen, F. J.; Deshaies, R. "Selective, reversible inhibitors of the AAA ATPase p97." 2011 Apr 14 [updated 2013 May 01]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133422/ PMID: 23658965.

Sharlow, E.; Golden, J. E.; Dodson, H.; Morris, M.; Hesser, M.; Lyda, T.; Leimgruber, S.; Schroeder, C. E.; Flaherty, D. P.; Weiner, W. S.; Simpson, D.; Lazo, J. S.; Aubé, J.; Morris, J. C. "Identification of Inhibitors of Trypanosoma brucei Hexokinases." 2010 Dec 15 [updated 2011 Jun 24]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK63599/ PMID: 21961120.

Strouse, J. J.; Ivnitski-Steele, I.; Njus, H. M.; Foutz, T. D.; Yao, T.; Weiner, W. S.; Schroeder, C. E.; Simpson, D. S.; Maki, B. E.; Li, K.; Golden, J. E.; Waller, A.; Evangelisti, A. M.; Young, S. M.; Perez, D.; Chavez, S. E.; Garcia, M. J.; Ursu, O.; Fara, D. C.; Bologa, C. G.; Carter, M. B.; Salas, V. M.; Tegos, G. P.; Oprea, T. I.; Edwards, B. S.; Larson, R. S.; Aubé, J.; Sklar, L. A. "Selective Efflux Inhibition of ATP-binding Cassette Sub-family G Member 2." 2010 Nov 30 [updated 2013 Feb 25]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK133425/ PMID: 23658968.

Hedrick, M. P.; Gosalia, P.; Li, K.; Frankowski, K. J.; Shi, S.; Prisinzano, T. E.; Schoenen, F.; Aubé, J.; Su, Y.; Stonich, D.; Vasile, S.; Sergienko, E.; Gray, W.; Hariharan, S.; Milan, L.; Heynen-Genel, S.; Vicchiarelli, M.; Mangravita-Novo, A.; Streicher, J. M.; Smith, L. H.; Chung, T. D. Y.; Caron, M.; Bohn, L. M.; Barak, L. S. "Antagonist for the Kappa Opioid Receptor." 2010 Oct 31 [updated 2011 May 26]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK66151/ PubMed PMID: 22091479.

Hedrick, M. P.; Gosalia, P.; Frankowski, K.; Shi, S.; Prisinzano, T. E.; Schoenen, F.; Aubé, J.; Su, Y.; Vasile, S.; Sergienko, E.; Gray, W.; Hariharan, S.; Ghosh, P.; Milan, L.; Heynen-Genel, S.; Chung, T. D. Y.; Dad, S.; Caron, M.; Bohn, L. M.; Barak, L. S. "Selective KOP Receptor Agonists: Probe 1 & Probe 2." 2010 Feb 28 [updated 2010 Oct 4]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK50694/ PMID: 21433386.

Hedrick, M. P.; Gosalia, P.; Frankowski, K.; Whipple, D. A.; Shi, S.; Prisinzano, T. E.; Schoenen, F.; Aubé, J.; Su, Y.; Vasile, S.; Sergienko, E.; Gray, W.; Hariharan, S.; Milan, L.; Heynen-Genel, S.; Chung, T. D. Y.; Dad, S.; Caron, M.; Bohn, L. M.; Barak, L. S. "Selective KOP Receptor Antagonists: Probe 1." 2010 Feb 28 [updated 2010 Oct 4]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK50689/ PMID: 21433381.

Surviladze, Z.; Waller, A.; Strouse, J. J.; Bologa, C.; Ursu, O.; Salas, V.; Parkinson, J. F.; Phillips, G. K.; Romero, E.; Wandinger-Ness, A.; Sklar, L. A.; Schroeder, C.; Simpson, D.; Nöth, J.; Wang, J.; Golden, J.; Aubé, J. "A Potent and Selective Inhibitor of Cdc42 GTPase." 2010 Feb 27 [updated 2010 Dec 16]. Probe Reports from the NIH Molecular Libraries Program [Internet]. Bethesda (MD): National Center for Biotechnology Information (US); 2010-. Available From http://www.ncbi.nlm.nih.gov/books/NBK51965/ PMID: 21433396.

 


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