NIH Molecular Libraries Probe Production Centers Network (MLPCN)

Probe Development and Extended Characterization Projects

Project Title Chemical optimization and mechanistic study of a broad spectrum antiviral inhibitor discovered from an anti-VEEV HTS
Grant Number 1 R03 MH087448-01A1
Assay Provider Donghoon Chung, University of Louisville
MLPCN Screening Center n/a

Project Title Development of an irreversible AAA ATPAse p97 inhibitor based on the SAR for ML240/241, structure-based inhibitor design (co-crystallography and molecular modeling of ML240/241 analogues with p97), in vitro and in vivo potency and selectivity assays specific for irreversible inhibitors, and physicochemical property assays
Grant Number 1 R03 MH085687-01
Assay Provider Raymond J. Deshaies, California Institute of Technology
MLPCN Screening Center n/a

Project Title Improvement of CL-00121MLS-047281 through additional biological characterization and medicinal chemistry optimization
Grant Number 1 R03 MH094180-01
Assay Provider Raymond J. Deshaies, California Institute of Technology
MLPCN Screening Center n/a

Project Title Small Molecules Targeting the Mitochondrial Permeability Transition
Grant Number 1 R03 DA033978-01
Assay Providers Michael A. Forte and Dennis Neil Bourdette, Oregon Health and Science University
MLPCN Screening Center n/a

Project Title SARS CoV inhibitors and imaging probes that target the papain-like protease
Grant Number P01 AI060915
Assay Provider Andrew Mesecar, Purdue University
MLPCN Screening Center n/a

Project Title Tuning of cellular efficacy and profiling of cross-species antiparasitic potential by additional SAR rounds by synthesis of Trypanosoma brucei hexokinase 1 inhibitors
Grant Number 1 R03 MH082340-01A1
Assay Provider James Morris, Clemson University
MLPCN Screening Center n/a

Project Title Structure activity relationship and mechanism of action studies for a probe compound identified and initially characterized in the MLPCN project, "Screening for Inhibitors of Bacterial Capsule Biogenesis"
Grant Number 1 R03 MH09079-01
Assay Provider Patrick C. Seed, Duke University
MLPCN Screening Center n/a

Project Title Tuning of cellular efficacy and enhancement of physiochemical properties for in vivo assessment of human respiratory syncytial virus (hRSV) inhibitors
Grant Number 1 R03 MH082403-01A1
Assay Provider William Severson, University of Louisville
MLPCN Screening Center n/a

Project Title Characterization of a Small Molecule Pan-Inhibitor of GTPases, ML282, and Efforts to Achieve Specificity
Grant Number 1 R03 MH081231-01
Assay Provider Angela Wandinger-Ness, University of New Mexico
MLPCN Screening Center University of New Mexico Center for Molecular Discovery

Project Title Extended Characterization of Cdc42 Probe: Mechanism of Actions and Application to Cancer and Infectious Disease
Grant Number 1 R03 MH081231-01
Assay Provider Angela Wandinger-Ness, University of New Mexico
MLPCN Screening Center University of New Mexico Center for Molecular Discovery

 

 

 

 


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